Natural and environmental oestrogens increase expression of SS-A/Ro autoantigen in the salivary gland of ovariectomized immature rats
| Autor: | Hiroyuki Aikawa, Mariko Onoe, Takaaki Kinoue, Kou Sakabe, Takahiko Yoshida, Fujio Kayama, Masahiko Okuma |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Salivary gland Cell Autoantibody Stimulation In situ hybridization Biology Reverse transcriptase Pathology and Forensic Medicine law.invention medicine.anatomical_structure Endocrinology law Physiology (medical) Internal medicine medicine Ovariectomized rat Polymerase chain reaction |
| Zdroj: | Pathophysiology. 6:231-236 |
| ISSN: | 0928-4680 |
| DOI: | 10.1016/s0928-4680(99)00020-6 |
| Popis: | SS-A/Ro autoantibodies are detected at high levels in patients with autoimmune diseases such as Sjogren’s syndrome. It has been reported that natural oestrogen is capable of inducing cell surface expression of SS-A/Ro autoantigens in salivary glands. We analyzed the effect of environmental oestrogens (i.e. oestrogenic xenobiotics) on the expression of the 52 kDa SS-A/Ro autoantigen in the rat salivary gland by reverse transcriptase polymerase chain reaction (RT-PCR) and in situ hybridization (ISH). Plant- or plastic-derived environmental oestrogens induced up to approximately 3.5-fold increase in 52 kDa SS-A/Ro mRNA levels in rat salivary gland compared to levels in untreated animals. The ISH results paralleled the RT-PCR results. These findings suggest that environmental oestrogen stimulation can induce the expression of autoantigens such as SS-A/Ro. |
| Databáze: | OpenAIRE |
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