Role and advantage of cystatin C in kidney function monitoring during retroviral therapy
| Autor: | Jakub Gburek, Maria Warwas, Katarzyna Juszczyńska, Ewa Mulewicz |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Diagnostyka Laboratoryjna. 53:33-40 |
| ISSN: | 2719-7042 0867-4043 |
| DOI: | 10.5604/01.3001.0013.7961 |
| Popis: | The aim of the study is to evaluate the utility of cystatin C (Cys C) determination in monitoring of HIV seropositive patients, based on recent literature concerning clinical investigation. Determination of serum CysC concentration can be helpful in monitoring the kidney function and eGFR (estimated GFR) calculation, however infection and inflammation markers influence should be included. A risk assessment of the appearance of cardiovascular incidents and risks of the all-cause mortality can be the other application for this parameter. The urinary CysC concentration can serve as the diagnostic marker of kidney tubular injuries triggered with adverse effects of antiretroviral drugs eg. tenofovir. In order to introduce applications into the routine clinical practice, further research is essential. Research concerning antiviral activity of cystatin C suggest, that CysC suppresses the viral replication due to inhibition of HIV protease, but in some cases its inhibitory effect on cathepsin B may be harmful and cause progression of the infection. In order that CysC could effectively use in the future, further experiments are needed to evaluate its effect on all sort virus strains, both dependent and independent of CD4+ T-lymphocytes, strains of the HIV virus. |
| Databáze: | OpenAIRE |
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