Impact of Preoperative Serum Tumor Markers in Patients with Lung Squamous Cell Carcinoma
| Autor: | Ryo Maeda, Shoei Kuroki, Masaki Tomita, Takanori Ayabe, Tomoka Hamahiro |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Peripheral type Lung biology business.industry Lung squamous cell carcinoma General Medicine Squamous cell carcinoma Antigen Gastroenterology Carcinoembryonic antigen medicine.anatomical_structure Internal medicine biology.protein Medicine In patient Tumor location business Male gender |
| Zdroj: | Advances in Lung Cancer. 10:48-55 |
| ISSN: | 2169-2726 2169-2718 |
| Popis: | Background: Several previous researchers have investigated the prognostic value of serum tumor markers, especially carcinoembryonic antigen (CEA). Only a limited number of studies reported the usefulness of serum tumor markers for lung squamous cell carcinoma (SQ). We aimed to examine the significance of serum tumor markers for lung SQ. Methods: Eighty-five lung SQ patients who underwent surgery and followed more than 5-year were included. The ratios of 5-year survivors to all patients in groups with several clinicopathologic factors, including tumor markers, were compared. We also compared the clinicopathologic factors between central type and peripheral type SQ. Results: The majority of patients were male gender and current/ former smokers. Age, pN status, cytokeratin-19 fragment (CYFRA 21-1), squamous cell carcinoma antigen (SCC), and comorbid interstitial pneumonia (IP) were associated with the ratio of 5-year survivors significantly. When patients were compared based on tumor location, high p-stage and CYFRA 21-1 were related to central type SQ. Conclusion: Both SCC and CYFRA 21-1 appeared to be useful prognostic markers for patients with lung SQ. Furthermore, CYFRA 21-1 was related to central type SQ. |
| Databáze: | OpenAIRE |
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