UPLC-MS-ESI-QTOF characterization and evaluation of the antibacterial and modulatory antibiotic activity of Ziziphus joazeiro Mart. aqueous extracts
| Autor: | Thalia da Silva de Freitas, Jacqueline Cosmo Andrade, Edy de Sousa Brito, Maria Flaviana Bezerra Morais-Braga, Maria Isabeli Pereira Gonçalo, Armínio Santos, Anelise Silva, Joara Nályda Pereira Carneiro, Paulo Riceli Vasconcelos Ribeiro, A. S. de Q. Souza, Henrique Douglas Melo Coutinho, Marcelo Bertonny Alves Freitas |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Active ingredient biology Traditional medicine Chemistry Broth microdilution Plant Science Ziziphus biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry visual_art Rhamnaceae Maceration (wine) visual_art.visual_art_medium Bark Medicinal plants Antibacterial activity 010606 plant biology & botany |
| Zdroj: | South African Journal of Botany. 123:105-112 |
| ISSN: | 0254-6299 |
| Popis: | Plant extracts are defined as complex heterogeneous mixtures composed of diverse active ingredient categories which characterize their bioactivities. Ziziphus joazeiro Mart., belonging to the Rhamnaceae family, is an endemic caatinga species with a wide economic potential and application in medicine. In the search for new antibacterial drugs, due to the manifestation and development of bacterial antibiotic resistance mechanisms, medicinal plants, with their broad pharmacological aspects, have led to the development of several phytomedicines. With this in mind, the objective of the present study was to identify the chemical composition of the Ziziphus joazeiro leaf and stem bark aqueous extracts through the UPLC–QTOF-MS/MS method, as well as to verify their antibacterial and modulatory action. Cold extract maceration was used to prepare the Z. joazeiro leaf and stem bark aqueous extracts (AEL and AEB). The broth microdilution method was used for the antibacterial and modulatory activity evaluations. This study is the first to report on the Ziziphus joazeiro extract analyzes by ultra-performance liquid chromatography. The UPLC-MS-ESI-QTOF analysis revealed compounds already present in the Ziziphus genus. The extracts did not present antibacterial activity, however, they presented significant modulatory activity when combined with antibiotics. The results highlight the need for further detailed compound identification analysis and toxicity evaluation of these extracts. |
| Databáze: | OpenAIRE |
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