Bioinspired Camellia japonica carbon dots with high near-infrared absorbance for efficient photothermal cancer therapy

Autor:	Gayoung Jo, Eun Jeong Kim, Bo Young Lee, Dohun Kim, Hoon Hyun, Uk Sim, Yujin Chae, Min-Kyung Ji, Surendran Subramani
Rok vydání:	2021
Předmět:	Absorbance Materials science Biocompatibility chemistry Near-infrared spectroscopy Photothermal effect chemistry.chemical_element General Materials Science Nanotechnology Laser power scaling Photothermal therapy Absorption (electromagnetic radiation) Carbon
Zdroj:	Nanoscale. 13:14426-14434
ISSN:	2040-3372 2040-3364
DOI:	10.1039/d1nr03999g
Popis:	Since carbon dots (CDs) exhibit excellent biocompatibility, low cytotoxicity, near-infrared (NIR) absorbance, and superior photostability, many types of CDs are considered as powerful candidates for photothermal therapy (PTT) applications. However, the development of a desirable CD is still difficult due to insufficient photothermal conversion, thus resulting in the use of high laser power densities at a high dose of CDs for the PTT effect. Herein, bioinspired sulfur-doped CDs (S-CDs) with strong NIR absorbance were prepared from Camellia japonica flowers via a facile hydrothermal method for enhancing the photothermal conversion efficiency. The as-prepared S-CDs exhibited various advantages including cost-effective preparation, good water-solubility, high biocompatibility, intense NIR absorption, and excellent photothermal effect with robust photostability. Most importantly, the optimal low dose of S-CDs (45 μg mL−1) successfully led to efficient PTT performance with a high photothermal conversion efficiency (55.4%) under moderate laser power (808 nm, 1.1 W cm−2) for safe and effective cancer therapy.
Databáze:	OpenAIRE
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