AN OBSERVATIONAL STUDY OF GENETIC ANTICIPATION AND GENOMIC IMPRINTING IN INDIAN FAMILIES WITH BIPOLAR AFFECTIVE DISORDER

Autor:	Vijendra Nath Jha, Pramod Kumar Singh
Rok vydání:	2017
Předmět:	Bipolar affective disorders Genetic Anticipation Age of onset Imprinting
DOI:	10.5281/zenodo.569476
Popis:	Introduction – Bipolar affective disorder is known to have the strong genetic component among psychiatric disorders. Non- Mendelian patterns of inheritance like Genetic anticipation and Genomic Imprinting have been reported with this illness. This study was done to observe these two phenomena in Indian families with bipolar affective disorder. Material and Methods – 24 families with unilineal inheritance of Bipolar affective disorder in parental-offspring pairs were selected for the study purpose and appropriate statistical measures were applied to various disease measures. Results – A significant difference was found with an earlier age of onset of illness (p Conclusion – Our results suggest the presence of genetic anticipation in Indian families with bipolar affective disorder.
Databáze:	OpenAIRE
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