Brief Report: Impact of Early Antiretroviral Therapy on the Performance of HIV Rapid Tests and HIV Incidence Assays

Autor:	Dean Soko, Tamara Walsky, Gerald Tegha, Mina C. Hosseinipour, Ying Q. Chen, Laeyendecker Oliver, Theresa Gamble, Ethan A. Wilson, Katherine Schlusser, Barbara Debevec, Estelle Piwowar-Manning, Johnstone Kumwenda, Marybeth McCauley, Susan H. Eshleman, Myron S. Cohen, Jessica M. Fogel
Rok vydání:	2017
Předmět:	0301 basic medicine HPTN 052 medicine.medical_specialty medicine.diagnostic_test business.industry Incidence (epidemiology) Hiv incidence 030112 virology Antiretroviral therapy Virology law.invention Clinical trial 03 medical and health sciences 0302 clinical medicine Infectious Diseases Randomized controlled trial law Internal medicine Immunoassay Medicine Pharmacology (medical) 030212 general & internal medicine business Viral load
Zdroj:	JAIDS Journal of Acquired Immune Deficiency Syndromes. 75:426-430
ISSN:	1525-4135
DOI:	10.1097/qai.0000000000001421
Popis:	BACKGROUND Antiretroviral therapy (ART) can downregulate antibody responses to HIV infection. We evaluated the impact of early vs. delayed ART on the performance of HIV diagnostic and incidence assays. METHODS Samples were obtained from 207 participants in the HPTN 052 trial, who were stably suppressed on ART for ≥4 years [Malawi sites; pre-ART CD4 cell count 350-550 cells/mm (early ART arm, N = 180) or
Databáze:	OpenAIRE
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