| Autor: |
E. C. Barbeta, G. A. Martín-Henao, J. R. G. Ronda, R. N. Soldevila, J. M. S. Villegas, A. E. Codins, M. P. Bosch, A. P. Oyarzabal, J. M. Sánchez, M. S. Bruguera, P. M. Resano, D. C. Caiz, L. R. Infante, P. P. Manero, L. M. Bosch |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Vox Sanguinis. 99:267-273 |
| ISSN: |
0042-9007 |
| DOI: |
10.1111/j.1423-0410.2010.01341.x |
| Popis: |
Background and Objectives The infusion of thawed haematopoietic progenitor cells from apheresis (HPC-A) is associated with minor but frequent adverse reactions (ARs), which has been mainly attributed to dimethyl sulphoxide (DMSO). Nevertheless, other factors may play a role in the pathogenesis of such toxicity. Materials and Methods The ARs on a cohort of 423 cryopreserved HPC-A infusions for 398 patients in HPC transplantation program were analysed. Results ARs were reported in 105 graft infusions (24·8%) and most of them were graded as mild to moderate. The most frequently reported ARs were gastrointestinal and respiratory, and three patients presented epileptic seizure. The volume of DMSO/kg (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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