| Autor: |
S. R. Hall, L. C. Campbell, D. M. Milne, U. Knippschild, L. J. Jardine, David W. Meek, L. McKendrick |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Cell Growth and Oncogenesis ISBN: 9783764357276 |
| Popis: |
The p53 tumour suppressor protein is a central component of the cell’s defence against agents which cause cancer. p53 is a nuclear DNA-binding phosphoprotein which encompasses a number of activities, including a potent transactivation function. Activation of p53 is initiated by a range of stresses including DNA damage and leads to cellular growth arrest or programmed cell death. We have shown that p53 undergoes extensive multi-site phosphorylation. Of the many signaling pathways which mediate this phosphorylation, one is responsive to ultraviolet radiation and may be mediated by members of the JNK family of stress-activated protein kinases. Another pathway, involving members of the casein kinase 1 family, is activated by DNA damage-inducing drugs in a mechanism that is dependent on p53 itself. These findings support the idea that multi-site phosphorylation may mediate the sensitivity of p53 to a range of environmental stresses. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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