Effect of Surgery Versus Observation: Skeletal 5-Year Outcomes in a Randomized Trial of Patients With Primary HPT (the SIPH Study)
| Autor: | Mikael Hellström, Ansgar Heck, Jörgen Nordenström, Karolina Lundstam, Jens Bollerslev, Thord Rosén, Kristin Godang, Ola Hessman, Turid Aas, Marek Baranowski, Charlotte L. Mollerup, Svante Jansson, Ylva Pernow |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
Parathyroidectomy medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Asymptomatic law.invention Bone remodeling 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Orthopedics and Sports Medicine 030212 general & internal medicine Femoral neck Bone mineral business.industry medicine.disease Skeleton (computer programming) Surgery medicine.anatomical_structure medicine.symptom business Primary hyperparathyroidism |
| Zdroj: | Journal of Bone and Mineral Research. 32:1907-1914 |
| ISSN: | 0884-0431 |
| DOI: | 10.1002/jbmr.3177 |
| Popis: | Mild primary hyperparathyroidism (PHPT) is known to affect the skeleton, even though patients usually are asymptomatic. Treatment strategies have been widely discussed. However, long-term randomized studies comparing parathyroidectomy to observation are lacking. The objective was to study the effect of parathyroidectomy (PTX) compared to observation (OBS) on bone mineral density (BMD) in g/cm2 and T-scores, and on biochemical markers of bone turnover (P1NP and CTX-1), in a prospective randomized controlled study of patients with mild PHPT after 5 years of follow-up. Of 191 patients with mild PHPT randomized to either PTX or OBS, 145 patients remained for analysis after 5 years (110 with validated DXA-scans). A significant decrease in P1NP (P |
| Databáze: | OpenAIRE |
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