Beta-receptor desensitization evoked by a multistage ultralong distance exercise in the desert?

Autor:	Marianne Zeller, Yves Cottin, V. Pasquereau, O. Ganansia, Carole Richard, Frédéric Chagué, F. Compagnon, F. Carré, Aurélie Gudjoncik
Rok vydání:	2021
Předmět:	Cardiac function curve medicine.medical_specialty business.industry medicine.medical_treatment Mean age Desensitization (psychology) Contractility Preload Internal medicine Heart rate Cardiology End-diastolic volume Medicine Statistical analysis Cardiology and Cardiovascular Medicine business
Zdroj:	Archives of Cardiovascular Diseases Supplements. 13:116
ISSN:	1878-6480
DOI:	10.1016/j.acvdsp.2020.10.244
Popis:	Background Few studies addressed to the evolution of cardiac function during a multistage ultra-long duration exercise (MULDE). Methods Serial echocardiographic assessment of cardiac function was performed in male healthy subjects during the 2014 Marathon des Sables before the race (T1), at the second (T2) and fifth (T3) arrival (236 km) then after 48 h recovery. Analysis were performed by 2 sonographers blind for the results of the other and the time of measure. Statistical analysis was performed using ANOVA-RM to compare the evolution of the different parameters. Results Among the 20 athletes, 18 completed the study (mean age 42.4, median 42). RR intervals and (Left ventricular End Diastolic Volume (Simpson) (LVEDV) changed during the race and were correlated (r2 = 0.539, P Table 1 ). Conclusions 48 h after a MULDE, we observed a drop in heart rate and contractility response to preload. The evolution of these parameters could be explained by a beta-receptors desensitization. These data need to be confirmed by other studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::20e8a820f27806edf6db2606fac3f3ae https://doi.org/10.1016/j.acvdsp.2020.10.244 Zobrazit plný text záznamu Full Text from ScienceDirect