Development of a Scalable Synthesis of Mevidalen (LY3154207), an Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor
| Autor: | Katarina Kadlecikova, John R. Rizzo, Mo Jia, Peter G. Houghton, Conchita Fernandez Garcia, Kevin P. Cole, Jeffery Richardson, Jared L. Piper, Junliang Hao, Amy C. DeBaillie, Peng Liu, Daniel S. Richards, Ping Huang |
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| Rok vydání: | 2020 |
| Předmět: |
Allosteric modulator
010405 organic chemistry Chemistry Tetrahydroisoquinoline Organic Chemistry Flow chemistry 010402 general chemistry 01 natural sciences Chemical synthesis Cocrystal Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Dopamine receptor D1 Hydroxybenzoate Dopamine medicine Physical and Theoretical Chemistry medicine.drug |
| Zdroj: | Organic Process Research & Development. 24:2549-2564 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.0c00229 |
| Popis: | The evolution from early medicinal chemistry to large-scale production of the chemical synthesis of Lilly D1 positive allosteric modulator mevidalen (LY3154207) and its hydroxybenzoate cocrystal is... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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