Ligand-receptor interactions of the low density lipoprotein receptor-related protein, a multi-ligand endocytic receptor

Autor:	Ivo R. Horn, Hans Pannekoek, A.J. van Zonneveld, B. M. van den Berg, Jaap G. Neels
Rok vydání:	1998
Předmět:	Low-density lipoprotein receptor gene family LRP1B Endocytic cycle Cell migration Biology LRP1 Cell biology chemistry.chemical_compound Biochemistry chemistry Low-density lipoprotein LDL receptor lipids (amino acids peptides and proteins) Receptor
Zdroj:	Fibrinolysis and Proteolysis. 12:219-240
ISSN:	1369-0191
DOI:	10.1016/s0268-9499(98)80016-7
Popis:	Summary The low density lipoprotein receptor-related protein (LRP) is a large membrane glycoprotein that is a member of the low density lipoprotein (LDL) receptor family of endocytic receptors. In contrast to the restricted ligand specificity of the LDL receptor, LRP can bind and internalize a remarkable spectrum of structurally-unrelated classes of ligands suggesting a role for the receptor in diverse physiological and patho-physiological processes ranging from lipoprotein metabolism, cell growth and cell migration to atherosclerosis and Alzheimer's disease. In this review we will summarize the current insights in the biology of LRP and particularly focus on the recent progress in our understanding of the molecular mechanisms that enable LRP to interact specifically with such a multitude of different ligands.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::20e575a07e08c3e2f8444275e23991f2 https://doi.org/10.1016/s0268-9499(98)80016-7 Zobrazit plný text záznamu Full Text from ScienceDirect