Synergism between sinusoidal-50 Hz magnetic field and formaldehyde in triggering carcinogenic effects in male Sprague-Dawley rats
| Autor: | Fabiana Manservisi, Fiorella Belpoggi, Michela Padovani, Livio Giuliani, Morando Soffritti, Eva Tibaldi, David G. Hoel, Laura Falcioni, Michelina Lauriola, Luciano Bua, Marco Manservigi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty business.industry Thyroid Public Health Environmental and Occupational Health Formaldehyde Physiology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure chemistry Natural death Untreated control 030220 oncology & carcinogenesis Male rats medicine Sprague dawley rats business Carcinogen |
| Zdroj: | American Journal of Industrial Medicine. 59:509-521 |
| ISSN: | 0271-3586 |
| Popis: | Background Experimental rodent bioassays performed up to now have failed to provide conclusive confirmation of the carcinogenicity of extremely low frequency magnetic fields (ELFMF). Objectives To evaluate the potential synergistic carcinogenic effects of concurrent exposure to ELFMF and formaldehyde in four groups of male and female Sprague–Dawley rats. Methods One group was exposed from prenatal life until natural death to S-50 Hz MF and to formaldehyde in drinking water from 6 weeks of age for 104 weeks, two groups were treated only with formaldehyde or only with MF and one group served as untreated control. Results Compared to untreated controls, exposure to MF and formaldehyde causes in males a statistically significant increased incidence of malignant tumors (P ≤ 0.01), thyroid C-cell carcinomas (P ≤ 0.01), and hemolymphoreticular neoplasias (P ≤ 0.05). No statistically significant differences were observed among female groups. Conclusions Life-span exposure to MF and formaldehyde induces statistically significant carcinogenic effects in male rats. Am. J. Ind. Med. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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