Metal-free tandem Beckmann–electrophilic aromatic substitution cascade affording diaryl imines, ketones, amines, and quinazolines
Autor: | Daniel P. Becker, Samuel R.S. Sarsah, Kailyn Chichi Bobb, Marlon R. Lutz |
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Rok vydání: | 2015 |
Předmět: | |
Zdroj: | Tetrahedron Letters. 56:5390-5392 |
ISSN: | 0040-4039 |
Popis: | A cascade reaction sequence involving a Beckmann rearrangement on benzophenone oxime followed by an electrophilic aromatic substitution (EAS) on the intermediate nitrilium ion affords N-phenyl diaryl imines that may then be hydrolyzed to ketones, or reduced to the corresponding amines. Reaction with benzonitrile afforded 2,4-diphenylquinazoline through a Beckmann–Ritter–EAS cascade. |
Databáze: | OpenAIRE |
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