Metal-free tandem Beckmann–electrophilic aromatic substitution cascade affording diaryl imines, ketones, amines, and quinazolines

Autor:	Daniel P. Becker, Samuel R.S. Sarsah, Kailyn Chichi Bobb, Marlon R. Lutz
Rok vydání:	2015
Předmět:	Substitution reaction Organic Chemistry Electrophilic aromatic substitution Oxime Biochemistry chemistry.chemical_compound Benzonitrile chemistry Cascade reaction Drug Discovery Beckmann rearrangement Benzophenone Organic chemistry Nitrilium
Zdroj:	Tetrahedron Letters. 56:5390-5392
ISSN:	0040-4039
Popis:	A cascade reaction sequence involving a Beckmann rearrangement on benzophenone oxime followed by an electrophilic aromatic substitution (EAS) on the intermediate nitrilium ion affords N-phenyl diaryl imines that may then be hydrolyzed to ketones, or reduced to the corresponding amines. Reaction with benzonitrile afforded 2,4-diphenylquinazoline through a Beckmann–Ritter–EAS cascade.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::20db37cec3704a821ac6cd63312311d0 https://doi.org/10.1016/j.tetlet.2015.07.095 Zobrazit plný text záznamu Full Text from ScienceDirect