The Fragmentation of Amine Cluster Ion Including HCl. Proton Affinities of Drugs of Abuse

Autor:	Shigeki Matsumura, Hideyuki Takezawa, Kimio Isa
Rok vydání:	2003
Předmět:	Fragmentation (mass spectrometry) Chemistry Analytical chemistry Proton affinity Amine gas treating Protonation Fast atom bombardment Mass spectrometry Affinities Medicinal chemistry Ion
Zdroj:	Journal of the Mass Spectrometry Society of Japan. 51:196-200
ISSN:	1880-4225 1340-8097
DOI:	10.5702/massspec.51.196
Popis:	The fragmentation of the cluster ion, [A1+HCl+A2+H]+ of amine bases A1 and A2, is studied by the BEBE type tandem mass spectrometer. The cluster ion, [A1+HCl+A2+H]+, is generated by the fast atom bombardment (FAB) ionization of mixture of two hydrochlorides of amines. The precursor ion is selected by the first analyzer (BE) and the product ions are scanned by the second analyzer (B/E linked scanning). The fragmentation of [A1+HCl+A2+H]+ yields two protonated monomers, [A1+H]+, [A2+H]+, and protonated heterodimer, [A1+HCl+A2+H]+. The relative abundances of [A1+H]+ and [A2+H]+ from the fragmentation of [A1+HCl+A2+H]+ are found to be related to their relative proton affinities and are used to determine the proton affinities (PAs) of methamphetamine and its analogs. The PA of methamphetamine is estimated to be 965 kJ/mol.
Databáze:	OpenAIRE
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