Abstract P319: Effects on Cardiac Output, Arterial Stiffness and Blood Pressure of Sacubyrtil + Valsartan in Hypertensive Patients With Heart Failure Whose Previously Received Ace Inhibitors or Arb + Diuretics. Prospective Study and Follow-up to 24 Weeks

Autor:	Ana Nuñez Galdamez, Caridad Turpin Lucas, Santiago Garcia Ruiz, Erik Stephan Luekpe, Ricardo Cabrera-Sole, Liliana Urrego Rivera, Manuel Aguilera Saldaña
Rok vydání:	2018
Předmět:	medicine.medical_specialty Cardiac output business.industry medicine.disease Sacubitril Blood pressure medicine.anatomical_structure Valsartan Ventricle Heart failure Internal medicine Internal Medicine medicine Arterial stiffness Cardiology Prospective cohort study business medicine.drug
Zdroj:	Hypertension. 72
ISSN:	1524-4563 0194-911X
DOI:	10.1161/hyp.72.suppl_1.p319
Popis:	Introduction: Hypertension (HTA), is behind a high percentage of patients with left ventricle dysfunction (LVHF) and the recent use of sacubitril + valsartan (ARNi), has revolutionized the treatment of heart failure. In hypertensive patients with LVHF, the use of this combination has been especially useful for clinical improvement and better control of blood pressure figures, however, we have little information about the effect of them on arterial stiffness (AS) and cardiac output (CO), for what we present the following work. Objectives: to evaluate the effect of ARNi on AS,CO and antihypertensive response in hypertensive patients with heart failure, who previously received ACE inhibitors or ARB. Material and Methods: we studied 48 patients (P) with LVHF from those we selected 38 P ( 68 ± 8 years old, 30 men) who had hypertension and were receiving ACEI or ARB alone or with diuretics for treatment. After discontinuing the previous treatment, ARNi was started until the tolerated dose and in all P had been done before introducing this drug and at 24 ± 2 weeks, a 24-hour ambulatory blood pressure study , and we measured the augmentation index (AI), pulse wave velocity (PWV), and CO non-invasively by means a MobilOgraph © device.The results were compared and exposed in the following table: Results: *means p value less than 0.05. Conclusions: use of ARNi, significantly improves the control of HTA as well as the AS, and CO of hypertensive patients with LVHF. There was also a tendency towards improvement, of the PWV, without reaching significant level, probably due to the number of patients studied, which provides more data of better prognosis to use ARNi in this group of patients.
Databáze:	OpenAIRE
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