Phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the synthesis of modified oligonucleotides

Autor:	Igor A. Prokhorenko, Maksim V. Kvach, N. V. Pilchenko, M. Yu. Tatulchenkov, Vladimir A. Korshun, O. L. Sharko, Sergey V. Gontarev, Irina A. Stepanova, M. E. Navakouski, Vadim V. Shmanai
Rok vydání:	2017
Předmět:	Phosphoramidite 010405 organic chemistry Oligonucleotide Organic Chemistry Oligonucleotide synthesis 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Biotin chemistry Acetylene Reagent Phase (matter) Bioorganic chemistry Organic chemistry
Zdroj:	Russian Journal of Bioorganic Chemistry. 43:386-396
ISSN:	1608-330X 1068-1620
DOI:	10.1134/s1068162017040148
Popis:	The synthesis of phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the introduction of the residues of biotin, lipoic acid, amino groups, and terminal acetylene groups at different positions of the oligonucleotide chain has been described. The efficiency of the reagents and supports has been confirmed by the synthesis of the corresponding modified oligonucleotides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::20bc3a71b739acfa5b170832d8c2c207 https://doi.org/10.1134/s1068162017040148 Zobrazit plný text záznamu Full text from SpringerLink