Efeitos da vitamina D na prevenção da bronquiolite viral aguda: revisão sistemática
| Autor: | Edgar Enrique Sarria-Icaza, Leonardo Araújo Pinto, Matheus Dorigatti Soldatelli, Matias Epifanio, Angélica Maria Barba Rueda, Eduardo Mundstock, Rafaela Becker, Rita Mattiello, Marcelo Comerlato Scotta, Ângela de Moura |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
business.industry MEDLINE Acute viral bronchiolitis General Medicine medicine.disease Clinical trial Ergocalciferol chemistry.chemical_compound chemistry Bronchiolitis Infectious disease (medical specialty) Internal medicine Vitamin D and neurology Medicine business Intensive care medicine Cholecalciferol medicine.drug |
| Zdroj: | Scientia Medica. 25:20313 |
| ISSN: | 1980-6108 1806-5562 |
| DOI: | 10.15448/1980-6108.2015.2.20313 |
| Popis: | Aims : Published evidence suggests that Vitamin D supplementation may have a protective effect on infectious disease of the lower respiratory tract. The objective of this review was to critically appraise the effects of vitamin D intake in the prevention of acute viral bronchiolitis in children. Methods: We searched the databases MEDLINE, EMBASE, Web of Science, LILACS, and Cochrane Central Register of Controlled Trials, until December 2014. Keywords: "Vitamin D" OR cholecalciferol OR ergocalciferol AND "bronchiolitis, viral" OR bronchiolitides, viral OR "bronchiolitides viral". Eligibility Criteria: We included studies evaluating the effect of vitamin D intake in the prevention of acute viral bronchiolitis in young children. Studies with less than two weeks of intervention and review articles were excluded. Results: The search identified 241 articles; twenty were selected for full reading but only two were included in the systematic review, comprising 296 children. No study measured serum vitamin D. One of them was a clinical trial, where the number of episodes of acute viral bronchiolitis was significantly lower in children supplemented with vitamin D (Group I: mean: 0.6 ± 0.7 Group II: mean: 1.4 ± 0.9; p = 0.001). The other, a case-control study, did not find a significant relationship between the occurrence of acute viral bronchiolitis cases and the intake of vitamin D (OR 1.7 95% CI 0.7 to 4.0). Conclusions: Current scientific evidence is insufficient to prove clinical benefits of vitamin D in preventing acute viral bronchiolitis. |
| Databáze: | OpenAIRE |
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