Synthesis and Some Transformations of 5-(1,4-Benzodioxan-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

Autor:	A. B. Sargsyan, S. A. Harutyunyan, A. S. Avagyan, A. A. Aghekyan, S. O. Vardanyan, H. V. Gasparyan
Rok vydání:	2020
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Benzodioxan chemistry Phenyl isothiocyanate Morpholine Organic Chemistry Thiol 1 2 4-Triazole Piperidine Alkali metal Medicinal chemistry Alkyl
Zdroj:	Russian Journal of Organic Chemistry. 56:436-439
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428020030112
Popis:	The title compound was synthesized by reaction of 1,4-benzodioxane-2-carbohydrazide with phenyl isothiocyanate, followed by cyclization of the N-phenylthiosemicarbazide thus formed in the presence of alkali. 5-(1,4-Benzodioxan-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol reacted with N-aryl(alkyl)-2-chloroacetoamides to give the corresponding S-substituted derivatives, and its Mannich condensation with piperidine and morpholine afforded 1-aminomethyl-1,2,4-triazole-5-thiones. The synthesized compounds were screened for antihypoxic activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::209d56f8a977dbb95912ff9ba84ba0ce https://doi.org/10.1134/s1070428020030112 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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