Crystal structures of (RS)-N-[(1R,2S)-2-benzyloxy-1-(2,6-dimethylphenyl)propyl]-2-methylpropane-2-sulfinamide and (RS)-N-[(1S,2R)-2-benzyloxy-1-(2,4,6-trimethylphenyl)propyl]-2-methylpropane-2-sulfinamide: two related protected 1,2-amino alcohols

Autor:	Louis J. Papa, Angelo M. Verderame, William W. Brennessel, Kevin P. McClelland, Michael D. Moskowitz, Adam Haas, Garrick A. Centola, Stephanie C. M. Dorn, Mikael S. Olezeski, Daniel J. Weix, Matthew R. Carbone
Rok vydání:	2014
Předmět:	Hydrogen bond Diastereomer General Chemistry Crystal structure Condensed Matter Physics Bioinformatics Ring (chemistry) Medicinal chemistry Crystal 2-Methyl propane chemistry.chemical_compound chemistry Sulfinamide General Materials Science Benzene
Zdroj:	Acta Crystallographica Section E Structure Reports Online. 70:365-369
ISSN:	1600-5368
DOI:	10.1107/s1600536814022570
Popis:	The title compounds, C22H31NO2S, (1), and C23H33NO2S, (2), are related protected 1,2-amino alcohols. They differ in the substituents on the benzene ring,viz.2,6-dimethylphenyl in (1) and 2,4,6-trimethylphenyl in (2). The plane of the phenyl ring is inclined to that of the benzene ring by 28.52 (7)° in (1) and by 44.65 (19)° in (2). In the crystal of (1), N—H...O=S and C—H...O=S hydrogen bonds link molecules, forming chains along [100], while in (2), similar hydrogen bonds link molecules into chains along [010]. The absolute structures of both compounds were determined by resonance scattering.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::20961566a2a0dd75f4399629846b8ba0 https://doi.org/10.1107/s1600536814022570 Zobrazit plný text záznamu