Effect of infrared radiation on the pharmacokinetics of 131I-mercaptododecaborate in animals with model tumors

Autor:	V. A. Yadrovskaya, A. P. Baranov, S. E. Ul'yanenko, E. P. Savina, S. N. Koryakin, Ya. V. Krivosheev
Rok vydání:	2005
Předmět:	Pharmacology Chemistry Melanoma Sodium Radiochemistry Analytical chemistry chemistry.chemical_element Radiation Iodine medicine.disease Neutron capture Pharmacokinetics Drug Discovery medicine Distribution (pharmacology) Irradiation
Zdroj:	Pharmaceutical Chemistry Journal. 39:627-629
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-006-0033-7
Popis:	The influence of local IR irradiation of the experimental melanoma B-16 zone on the distribution of sodium mercaptododecaborate labeled with radioactive iodine (131I-BSH) in mice was studied for two regimes of thermal treatment (before and after administration of the labeled compound). It was established that a considerable increase in the 131I-BSH content in the model tumor was reached in the case of IR irradiation performed 1 h after drug administration. Based on these data, IR radiation can be considered an effective modifier of 131I-BSH uptake in tumors, increasing the efficacy of boron-enhanced neutron capture therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2088597e792221b6df45f49d91d3491b https://doi.org/10.1007/s11094-006-0033-7 Zobrazit plný text záznamu Plný text ve formátu PDF