Allelic Combinations of Immune Response Genes and Risk of Development of Myocardial Infarction

Autor:	R. I. Sadikova, I. A. Tuktarova, M. Iu. Shein, Timur R. Nasibullin, Ya. R. Timasheva, Olga E. Mustafina, I. E. Nikolaeva, V. V. Erdman
Rok vydání:	2018
Předmět:	0301 basic medicine Polygenic disease Biology medicine.disease Human genetics 03 medical and health sciences 030104 developmental biology Increased risk Genetic marker Immunology Immune response genes Genetics medicine Homogeneous group Myocardial infarction Allele
Zdroj:	Russian Journal of Genetics. 54:472-481
ISSN:	1608-3369 1022-7954
DOI:	10.1134/s1022795418040130
Popis:	Myocardial infarction (MI) is a multifactorial polygenic disease. It develops because of the complex interaction between many environmental and genetic factors. In this paper, we have studied associations of MI and allele combinations of 17 polymorphic markers of immune response genes in an ethnically homogeneous group of Tatars. The material for analysis was DNA samples of patients (286 men) with onset of MI at the age of 30 to 60 years and 301 essentially healthy men of the control group. Using the APSampler algorithm, we obtained allele combinations with the increased risk of MI in which allele variants CX3CR1*M (rs3732378), VCAM1*C (rs3917010), ICAM1*E (rs5498), LTA*A (rs909253), and TNFRSF1B*M (rs1061622) occurred the most often.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::208728614a3dc077d33364aa78710c15 https://doi.org/10.1134/s1022795418040130 Zobrazit plný text záznamu Full text from SpringerLink