A Parent-Twin Study of Plasma Levels of Histidine-Rich Glycoprotein (HRG)

Autor:	Rune R. Frants, Dorret I. Boomsma, B.C. Hennis, Cornelis Kluft, A. G. M. Van Wees
Rok vydání:	1993
Předmět:	Genetics chemistry.chemical_classification medicine.medical_specialty Histidine-rich glycoprotein Offspring Hematology Heritability Biology Twin study Blood proteins Endocrinology chemistry Internal medicine Blood plasma Genotype medicine Glycoprotein
Zdroj:	Thrombosis and Haemostasis. 70:848-851
ISSN:	2567-689X 0340-6245
Popis:	SummaryHistidine-rich glycoprotein (HRG) is a non-enzymatic glycoprotein that acts as a modulator of several plasma proteins involved in coagulation and fibrinolysis. The contributions of genetic and environmental influences to inter-individual variation in plasma levels of HRG were studied in 160 Dutch families consisting of adolescent twin pairs and their parents. Results showed that 69% of the variance in plasma HRG concentrations could be accounted for by genetic factors. Heritability was the same in males and females and in parents and their offspring. There was no association between HRG levels of husband and wife and no evidence was found for the influence of shared family environment on the resemblance between relatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::20831fbd85a1341bfffe8763e6fc442c https://doi.org/10.1055/s-0038-1649681 Zobrazit plný text záznamu