| Popis: |
Background: Legg-Calvé-Perthes disease (LCPD) is a pediatric disorder that occurs due to the avascular necrosis of the femoral head and affects the range of motion of the hip in various degrees. Its etiology is still unknown, although it has been associated with coagulation abnormalities. In Mexico, there are no reports describing hypercoagulability markers in patients with LCPD. Therefore, our objective is to determine coagulation factors, Von Willebrand factor (VWF), and Homocysteine (Hcy) in patients with LCPD and controls.Results: Were tested 25 patients with LCPD and 50 controls, matched by sex and age. The results showed significant differences in patients whit respect to controls: Prothrombin time↘, FV↗, FVIII↗ FIX↗, and Hcy↗. These results indicate that there may be hypercoagulable states in patients, which can cause thrombotic events.Conclusions: This is the first report in Mexico with a clinical and research focus regarding patients with LCPD. The increase in FV activity, FVIII, FIX, and Hcy concentration support the hypothesis that microthrombi formation in small-caliber vessels could be causing avascularity and femoral necrosis, which are traits of LCPD. |
