Acid-catalysed ring-opening of N-(3, 4-dihydro-4-oxoquinazolin-3-yl)-substituted aziridines: aziridine ring-opening with retention of configuration

Autor:	Tony M. Raynham, William Gattrell, Robert S. Atkinson, Andrew P. Ayscough
Rok vydání:	1998
Předmět:	Chemistry Organic Chemistry chemistry.chemical_element Aziridine Ring (chemistry) Biochemistry Medicinal chemistry Oxygen law.invention chemistry.chemical_compound law Drug Discovery Quinazolinone Walden inversion
Zdroj:	Tetrahedron Letters. 39:4377-4380
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)00705-9
Popis:	The presence of the quinazolin-4(3H)-one (Q) ring in 1-(Q)-2-vinylaziridine (2) can be used to control the stereochemistry of the 3-membered ring-opening; participation by the quinazolinone carbonyl oxygen brings about ring-opening with retention of configuration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2082249f798d69cd7e5250b9f123f18e https://doi.org/10.1016/s0040-4039(98)00705-9 Zobrazit plný text záznamu Full Text from ScienceDirect