Simulating the pharmacokinetics of tabletized ambroxol using the dynamics of drug distribution in saliva

Autor:	S. N. Kondratenko, A. K. Starodubtsev, I. V. Zolkina, G. A. Belyakova
Rok vydání:	2009
Předmět:	Pharmacology Drug Saliva Chemistry media_common.quotation_subject Ambroxol Drug concentration Pharmacokinetics Drug Discovery Blood plasma Healthy volunteers medicine AMBROXOL HYDROCHLORIDE medicine.drug media_common
Zdroj:	Pharmaceutical Chemistry Journal. 43:77-80
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-009-0252-9
Popis:	The pharmacokinetics of ambrogexal (generic) and ambroxol (INN) tablets were investigated in 18 healthy volunteers after peroral administration in a single dose of 60 mg. The levels of ambroxol hydrochloride in saliva were significantly higher (statistically reliable) than those in the blood plasma for the first 1.5 hours after administration due to features of the drug absorption in the gastrointestinal tract. There are statistically reliable differences between the pharmacokinetic parameters (C max, T max, T 1/2, V z) calculated from the dynamics of ambroxol hydrochloride concentration in the saliva and plasma. Using the proposed method of extrapolation of the drug concentration, it is possible to use saliva for studying the pharmacokinetics of ambroxol administered in tabletized drug forms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2080414c928784c7a6cd4684b4dbaa17 https://doi.org/10.1007/s11094-009-0252-9 Zobrazit plný text záznamu Plný text ve formátu PDF