Circulating Endothelial Cells and Endothelial Function Predict Major Adverse Cardiac Events and Early Adverse Left Ventricular Remodeling in Patients With ST-Segment Elevation Myocardial Infarction

Autor:	Magdy Abdel Hamid, Sameh Bakhoum, Ahmed El-gengehe, Ahmed Abdel-Latif, Dina Sabry, Yasser Sharaf
Rok vydání:	2016
Předmět:	0301 basic medicine medicine.medical_specialty Ejection fraction Endothelium business.industry 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Internal medicine Heart failure cardiovascular system medicine Cardiology Radiology Nuclear Medicine and imaging cardiovascular diseases Myocardial infarction Myocardial infarction diagnosis Endothelial dysfunction Cardiology and Cardiovascular Medicine business Ventricular remodeling Mace
Zdroj:	Journal of Interventional Cardiology. 29:89-98
ISSN:	0896-4327
DOI:	10.1111/joic.12269
Popis:	Endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) are mobilized from the bone marrow and increase in the early phase after ST-elevation myocardial infarction (STEMI). The aim of this study was to assess the prognostic significance of CECs and indices of endothelial dysfunction in patients with STEMI. In 78 patients with acute STEMI, characterization of CD34+/VEGFR2+CECs, and indices of endothelial damage/dysfunction such as brachial artery flow mediated dilatation (FMD) were determined. Blood samples for CECs assessment and quantification were obtained within 24 hours of admission and FMD was assessed during the index hospitalization. At 30 days follow up, the primary composite end point of major adverse cardiac events (MACE) consisting of all-cause mortality, recurrent nonfatal MI, or heart failure and the secondary endpoint of early adverse left ventricular (LV) remodeling were analyzed. The 17 patients (22%) who developed MACE had significantly higher CEC level (P = 0.004), von Willebrand factor (vWF) level (P = 0.028), and significantly lower FMD (P = 0.006) compared to the remaining patients. Logistic regression analysis showed that CECs level and LV ejection fraction were independent predictors of MACE. The areas under the receiver operating characteristic curves (ROC) for CEC level, FMD, and the logistic model with both markers were 0.73, 0.75, and 0.82, respectively, for prediction of the MACE. The 16 patients who developed the secondary endpoint had significantly higher CEC level compared to remaining patients (P = 0.038). In conclusion, increased circulating endothelial cells and endothelial dysfunction predicted the occurrence of major adverse cardiac events and adverse cardiac remodeling in patients with STEMI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::207c96cf63fa8156280cf0ea0d04becc https://doi.org/10.1111/joic.12269 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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