| Popis: |
Publisher Summary The chapter summarizes the information concerning early virus-cell interaction published during the past decade. It also describes the general problems concerning attachment, penetration, and uncoating. Animal viruses are usually divided into two classes—those with a lipoprotein envelope and those without. The former class contains detectable amounts of lipid while the latter class does not. It is believed that the early virus-cell interaction for these two classes of viruses is different. An attractive role for viral envelope proteins is to effect attachment and penetration of the virus through the cell plasma membrane, thus providing efficient translocation of virus genetic material to the host cell. Surprisingly, nonenveloped viruses often follow a similar pathway in gaining entry into the cell suggesting that the functions of the virus envelope is superseded by surface proteins of these viruses. The complexity of the subject and the controversy surrounding it are presented fully and the gaps in the knowledge and ignorance of many points concerning early virus-cell interaction are indicated. |
