Characterization of Two Highly Homologous Autoantibody-Related VHl Genes in Humans

Autor:	Pei-Ming Yang, D. A. Carson, T. Olee, Pojen P. Chen
Rok vydání:	1993
Předmět:	Genetics Immunology Nucleic acid sequence General Medicine Immunogenetics Biology Molecular biology Germline Complementary DNA Consensus sequence biology.protein Antibody Gene Peptide sequence
Zdroj:	Scandinavian Journal of Immunology. 37:504-508
ISSN:	1365-3083 0300-9475
DOI:	10.1111/j.1365-3083.1993.tb03326.x
Popis:	Previously, we showed that the Humhallr rearranged gene was almost identical to the consensus amino acid sequence of several G6 idiotype-positive rheumatoid factor (RF) heavy chains, and to the VH gene-encoded region of the fetally expressed 51PI cDNA. The finding led us to suggest that the ha llr-corresponding germline gene encodes the heavy chains of many human IgM RFs. We now report the isolation of the proposed germline gene, designated Humhv 1051; it is identical to the consensus sequence of the G6 heavy chain V regions. During this experiment, we also isolated unexpectedly an additional VHl gene, termed Humhv 1051K; it differs from hv1051 by one amino acid residue. Importantly, hv1051K is identical to Humha 113, the rearranged VHl gene of a natural anti-cardiolipin antibody.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2073c210d960c2e390fdd4f95913bc03 https://doi.org/10.1111/j.1365-3083.1993.tb03326.x Zobrazit plný text záznamu Plný text