Prevention of Deep Vein Thrombosis after Major Knee Surgery - A Randomized, Double-Blind Trial Comparing a Low Molecular Weight Heparin Fragment (Enoxaparin) to Placebo
| Autor: | S Haviernick, J. R. Leclerc, Shannon Atkinson, J. Bourgouin, W. H. Geerts, F Laroche, Louis Desjardins, F. Jobin, F. Delorme |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test medicine.drug_class business.industry Deep vein medicine.medical_treatment Venography Low molecular weight heparin Hematology Heparin medicine.disease Placebo Thrombosis Arthroplasty Surgery Regimen medicine.anatomical_structure Anesthesia medicine business medicine.drug |
| Zdroj: | Thrombosis and Haemostasis. 67:417-423 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0038-1648463 |
| Popis: | SummaryConsecutive patients undergoing knee arthroplasty or tibial osteotomy at four participating hospitals received either enoxaparin, 30 mg subcutaneously every 12 h (n = 66) or an identicalappearing placebo (n = 65). All study medications started the morning after the operation and were continued up to a maximum of 14 days. Patients underwent surveillance with 125I-fibrinogen leg scanning and impedance plethysmography. Bilateral contrast venography was performed routinely at Day 14 or at time of discharge, if sooner. Deep vein thrombosis was detected by venography in 35 of 54 patients (65%) in the placebo group and in 8 of 41 patients in the enoxaparin group (19%), a risk reduction of 71%, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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