Effects of Insulin-Like Growth Factor I Combined with Growth Hormone on Glucocorticoid-Induced Whole-Body Protein Catabolism in Man1
| Autor: | Kaspar Berneis, Ulrich Keller, Ronald Ninnis, Brigitte M. Frey, Juerg Girard |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Catabolism Endocrinology Diabetes and Metabolism medicine.medical_treatment Growth factor Biochemistry (medical) Clinical Biochemistry Biology Placebo Biochemistry Protein catabolism Insulin-like growth factor Steroid hormone Endocrinology Methylprednisolone Internal medicine medicine Glucocorticoid medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 82:2528-2534 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.82.8.4143 |
| Popis: | Treatment with insulin-like growth factor I (IGF-I) alone failed to affect glucocorticoid-induced protein catabolism in a previous study from our laboratory. To assess the effects of the combination of IGF-I and GH in a similar protocol, 24 normal subjects received (in a double-blind, randomized, placebo-controlled manner) sc injections of either GH alone (0.3 IU/kg·day), the combination of IGF-I (80μ g/kg·day) and GH (0.3 IU/kg·day), or placebo for a period of 6 days during which they were treated with methylprednisolone (0.5 mg/kg·day). Whole-body protein kinetics measured, using the[ 1-13C]-leucine infusion technique, demonstrated that leucine flux (a parameter of protein breakdown) increased during administration of glucocorticoids alone (placebo group) and during GH-treatment, whereas the glucocorticoid-induced increase was abolished during IGF-I plus GH (P < 0.03 vs. GH). Leucine oxidation (a parameter of irreversible protein catabolism) increased in the placebo group (+60 ± 14.5%, P < 0.005, day 7 ... |
| Databáze: | OpenAIRE |
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