Towards a selective Boc deprotection on acid cleavable Wang resin

Autor:	Jean Martinez, Florine Cavelier, Valérie Lejeune
Rok vydání:	2003
Předmět:	chemistry.chemical_classification Wang resin stomatognathic system chemistry Cleave Organic Chemistry Drug Discovery Polymer chemistry technology industry and agriculture Peptide Polymer Cleavage (embryo) Biochemistry
Zdroj:	Tetrahedron Letters. 44:4757-4759
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(03)00993-6
Popis:	The Wang resin is one of the most commonly used solid polymers in SPPS. An Fmoc strategy for the lengthening of the peptide chain is compatible with the final acid cleavage of the peptide-resin bond. To increase tactic possibilities, it would be interesting to be able to use the Boc group on this resin type. Classical acid conditions (TFA 30 to 90% in DCM) for Boc removal cleave the peptide from the Wang resin simultaneously. Therefore, we investigated new conditions for deprotecting the Boc group which would preserve the peptide-resin bond.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2061570eb4493451abf1a0d9ce163610 https://doi.org/10.1016/s0040-4039(03)00993-6 Zobrazit plný text záznamu Full Text from ScienceDirect