| Popis: |
A new series of hydroquinolines 6a-d, 10, 12, 15, 17b, 20 and pyrimidoquinolines 7, 8, 9a, 11, 14 and 16 were synthesized starting from 2-amino-4-(3-bromo-phenyl)-7,7-dimethyl-1-naphthalen-1-yl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile 6b. The structures of the synthesized compounds were elucidated by elemental analyses and spectral data. Compounds 6a, 10, 11 and 18 exhibited a remarkable antifungal activity compared with fungicide Mycostatine. Radiosterilization of the biologically active compounds 6a, 10 and 11 in the dry state may prove to be applicable [retaining their structures unchanged up to (40 kGy)]. |
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