Peptidomimetic Inhibitors of Extracellular Aspartic Proteinases of Candida albicans and Candida tropicalis

Autor:	Ivana Křížová, Martin Hradilek, Iva Pichová, Martin Fusek, Tomáš Ruml, Milan Souček, Kateřina Brožková, L. Pavlíčková
Rok vydání:	1999
Předmět:	Candida tropicalis Scissile bond biology Biochemistry Peptidomimetic Chemistry Chromogenic Extracellular General Chemistry biology.organism_classification Candida albicans In vitro Corpus albicans
Zdroj:	Collection of Czechoslovak Chemical Communications. 64:130-137
ISSN:	1212-6950 0010-0765
DOI:	10.1135/cccc19990130
Popis:	In an attempt to develop effective inhibitors of Candida secreted aspartic proteinases, we have prepared a series of N-protected peptides varying in the type of scissile bond replacement, in the P and P' side chains as well as in the N- and C-terminal modifications. The compounds were tested in vitro with the chromogenic peptide substrate using purified secreted proteinases of C. albicans and C. tropicalis. Our results have confirmed that the binding of inhibitors and their effectiveness is influenced by a number of enzyme-inhibitor interactions. Moreover, factors like solvation/desolvation contribute to the optimal binding energy of the inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::20534d9f77c8d476f40c3104ab42c438 https://doi.org/10.1135/cccc19990130 Zobrazit plný text záznamu