Prediction of Axillary Lymph Node Metastases in a Screened Breast Cancer Population
| Autor: | Johan Ahlgren, Lars-Gunnar Arnesson, Gunnar Gunnar Westman, Olle Stål |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Oncology
medicine.medical_specialty Univariate analysis education.field_of_study Multivariate analysis business.industry Population Hematology General Medicine medicine.disease medicine.anatomical_structure Breast cancer Internal medicine Nodal status medicine Radiology Nuclear Medicine and imaging Stage (cooking) education business Pathological Lymph node |
| Zdroj: | Acta Oncologica. 33:603-608 |
| ISSN: | 1651-226X 0284-186X |
| Popis: | To define a subgroup of patients, in whom axillary dissection could be omitted, we analysed the frequency of pathologically confirmed lymph node metastases depending on tumour size, hormonal receptors, DNA ploidy, S-phase fraction (SPF), and clincial nodal status among 1 145 patients with stage I-II breast cancer from an area with ongoing screening. Clinical nodal status and tumour size were strongly correlated to pathological nodal status. Also SPF > 10% was strongly correlated to node positivity in univariate analysis. In multivariate analysis there was still a significant correlation among cases with tumour size ≤ 20 mm. In conclusion, patients with clincially negative nodal status, and tumour size ≤ 20 mm and ≤ 10 mm had pathologically positive nodes in 25% and 15% of cases respectively. The addition of SPF did not lower these figures significantly since small tumours with high SPF are few. |
| Databáze: | OpenAIRE |
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