Role of the NO-cGMP-K+ channels pathway in the peripheral antinociception induced by α-bisabolol
| Autor: | Raquel Cariño-Cortés, Gilberto Castañeda-Hernández, Mario I. Ortiz, Andrés Salas-Casas, Víctor Manuel Muñoz-Pérez |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 99:1048-1056 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/cjpp-2020-0744 |
| Popis: | The aim of this study was to examine if the peripheral antinociception of α-bisabolol involves the participation of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) synthesis followed by K+ channel opening in the formalin test. Wistar rats were injected in the dorsal surface of the right hind paw with formalin (1%). Rats received a subcutaneous injection into the dorsal surface of the paw of vehicles or increasing doses of α-bisabolol (100–300 µg/paw). To determine whether the peripheral antinociception induced by α-bisabolol was mediated by either the opioid receptors or the NO-cGMP-K+ channels pathway, the effect of pretreatment (10 min before formalin injection) with the appropriate vehicles, naloxone, naltrexone, NG-nitro-l-arginine methyl ester (L-NAME), 1H-[1,2,4]-oxadiazolo[4,2-a]quinoxalin-1-one (ODQ), glibenclamide, glipizide, apamin, charybdotoxin, tetraethylammonium, or 4-aminopyridine on the antinociceptive effects induced by local peripheral α-bisabolol (300 µg/paw) were assessed. α-Bisabolol produced antinociception during both phases of the formalin test. α-Bisabolol antinociception was blocked by L-NAME, ODQ, and all the K+ channels blockers. The peripheral antinociceptive effect produced by α-bisabolol was not blocked by the opioid receptor inhibitors. α-Bisabolol was able to active the NO-cGMP-K+ channels pathway to produce its antinoceptive effect. The participation of opioid receptors in the peripheral local antinociception induced by α-bisabolol is excluded. |
| Databáze: | OpenAIRE |
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