Solubility of Felodipine and Nitrendipine in Liquid and Supercritical Carbon Dioxide by Cloud Point and UV Spectroscopy

Autor:	William H. Hanlon, Randy D. Weinstein, Kenneth R. Muske, Michael Simeone, J. Patrick Donohue, and Anton Rozich
Rok vydání:	2006
Předmět:	Cloud point Supercritical carbon dioxide Chemistry General Chemical Engineering Inorganic chemistry Analytical chemistry General Chemistry Solvent chemistry.chemical_compound Ultraviolet visible spectroscopy Nitrendipine Carbon dioxide medicine Solubility medicine.drug Bar (unit)
Zdroj:	Journal of Chemical & Engineering Data. 52:256-260
ISSN:	1520-5134 0021-9568
Popis:	The solubility of two calcium channel blockers, felodipine and nitrendipine, was measured in liquid and supercritical carbon dioxide at (298, 308, and 318) K and at pressures between (80 and 250) bar. The solubilites were measured experimentally through two methods: cloud point measurements and UV absorption. At lower pressures, and hence densities, the UV method was more accurate while at higher pressures and densities the solubilities measured by both methods were basically identical. Both of these compounds showed an increase in solubility with increasing temperature and density. The experimentally determined solubility was accurately modeled using an equation, derived from association laws, which had a strong solvent density and temperature dependence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::20414d3580d5e7f4be03a11aebc35470 https://doi.org/10.1021/je0603729 Zobrazit plný text záznamu