| Autor: |
Liu-Zhu Chen, Hu-Wei Xia, Lu-Qian Zhan, Yi-Si Lin, Xue-Qian Xu, Jin-Cai He, Xiao-Qian Luan |
| Rok vydání: |
2022 |
| Předmět: |
|
| DOI: |
10.21203/rs.3.rs-1509675/v1 |
| Popis: |
Background and Purpose In patients with acute ischemic stroke (AIS) undergoing intravenous thrombolysis (IVT), there are few studies assessing the predictive effect of blood cell inflammatory markers on stroke-associated pneumonia (SAP), short-term and long-term prognosis. In this study, we evaluated whether the neutrophil-to-lymphocyte ratio (NLR) can predict SAP and functional prognosis in patients receiving IVT. Methods We assessed 388 patients undergoing IVT for acute ischemic stroke. Blood parameters were sampled before thrombolysis (within 30 mins after admission) and within 12–24 h after thrombolysis. The primary outcome measure was the occurrence of SAP as well as the prognosis after IVT. Multivariate logistic regression analysis was performed to analyze the association between NLR and the occurrence of SAP. We also used receiver operating characteristic curve analysis to assess the discriminative ability of NLR measured at different times in predicting SAP and prognosis. Further exploration of the correlation between NLR and baseline variables was conducted using Pearson correlation and multivariate linear regression analysis. Results Among the total patients, SAP occurred in 60 (15%) patients. Multivariate analysis showed that NLR was significantly associated with SAP (NLR before IVT: aOR = 1.288; 95%CI = 1.123–1.476; p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
