Production and Antifungal Activity of Cordytropolone and (-)-Leptosphaerone A From the Fungus Polycephalomyces nipponicus
| Autor: | Aphidech Sangdee, Prapairat Seephonkai, Nilawan Surapong, Kittipong Chainok, Stephen G. Pyne |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Pharmacology Antifungal 010405 organic chemistry medicine.drug_class Plant Science General Medicine Fungus Cordytropolone Biology biology.organism_classification 01 natural sciences 0104 chemical sciences Complementary and alternative medicine 010608 biotechnology Polycephalomyces nipponicus Polycephalomyces Drug Discovery Botany medicine |
| Zdroj: | Natural Product Communications. 14:1934578X1984412 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x19844120 |
| Popis: | Cordytropolone (1) and (−)-leptosphaerone A (2) were isolated from the culture broth of the fungus Polycephalomyces nipponicus. The structures of these two compounds were elucidated by spectroscopic methods and from a comparison of the spectroscopic data with those reported previously. The structure of 1 was confirmed by X-ray crystallography for the first time while the leptosphaerone class (compound 2) was first isolated as its (+)-antipode from the fungus Polycephalomyces ( Cordyceps). The fermentation process was monitored weekly by High performance liquid chromatography analysis for 10 weeks. The predominant compound (1) was produced at ~0.65 mg/mg of dry extract at week 9. Compound 1 exhibited modest antipathogenic fungal activity against Collectrichum musae, Colletotrichum capsici, Colletotrichum gloeosporioides, Fusarium spp. TFPK301, F. spp. FOC1708, and Pestalotia spp. with percentage of mycelial growth inhibition values of 3.74 ± 0.70%, 12.86 ± 1.43%, 0.91 ± 0.56%, 5.46 ± 0.56%, 7.93 ± 0.61%, and 18.75 ± 5.24%, respectively, at 25 μg/mL. |
| Databáze: | OpenAIRE |
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