Dopamine deficiency underlies learning deficits in neurofibromatosis-1 mice
| Autor: | David F. Wozniak, Kazuhiro Tokuda, Yukitoshi Izumi, Kelly A. Diggs-Andrews, Charles F. Zorumski, David H. Gutmann |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
biology
Dopaminergic Hippocampus medicine.disease Neurofibromin 1 Ventral tegmental area chemistry.chemical_compound medicine.anatomical_structure Neurology chemistry Dopamine medicine biology.protein Cyclic adenosine monophosphate Neurology (clinical) Neuron Neurofibromatosis Psychology Neuroscience medicine.drug |
| Zdroj: | Annals of Neurology. 73:309-315 |
| ISSN: | 0364-5134 |
| DOI: | 10.1002/ana.23793 |
| Popis: | Children with neurofibromatosis type 1 (NF1) are prone to learning and behavioral abnormalities, including problems with spatial learning and attention. The molecular etiology for these deficits is unclear, as previous studies have implicated defective dopamine, cyclic adenosine monophosphate (cAMP), and Ras homeostasis. Using behavioral, electrophysiological, and primary culture, we now demonstrate that reduced dopamine signaling is responsible for cAMP-dependent defects in neuron function and learning. Collectively, these results establish defective dopaminergic function as a contributing factor underlying impaired spatial learning and memory in children and adults with NF1, and support the use of treatments that restore normal dopamine homeostasis for select individuals. |
| Databáze: | OpenAIRE |
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