Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations

Autor:	Yasmin Issop, Sinead Harper, Andrew S.C. Rice, Nick Andrews
Rok vydání:	2011
Předmět:	Predictive validity business.industry General Neuroscience Analgesic Chronic pain medicine.disease General Biochemistry Genetics and Molecular Biology History and Philosophy of Science Action (philosophy) Anesthesia Plasma concentration Reflex Medicine business
Zdroj:	Annals of the New York Academy of Sciences. 1245:11-13
ISSN:	0077-8923
DOI:	10.1111/j.1749-6632.2011.06342.x
Popis:	We propose that predictive validity of tests for analgesia may be improved by looking to reinstate specific, innate behaviors suppressed by pain, e.g., burrowing, because effective plasma concentrations in the rat are closer to effective clinical plasma concentrations than those generally used in rodent reflex withdrawal assays.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2006fcfaa755d3f9a6e5c680aad391a5 https://doi.org/10.1111/j.1749-6632.2011.06342.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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