Enhancement Evaluation of Energy Deposition and Secondary Particle Production in Gold Nanoparticle Aided Tumor Using Proton Therapy

Autor:	Somaye Malmir, Saeed Mohammadi, Ali Asghar Mowlavi
Rok vydání:	2017
Předmět:	Cancer Research Materials science Monte Carlo method Sobp Nanoparticle Bragg peak Oncology Particle Deposition (phase transition) Pharmacology (medical) Radiology Nuclear Medicine and imaging Surgery Neutron Proton therapy Biomedical engineering
Zdroj:	International Journal of Cancer Management. 10
ISSN:	2538-497X 2538-4422
DOI:	10.5812/ijcm.10719
Popis:	Background: Numerous qualitative studies have been carried out on the safety and clinical use of GNPs as a radio-sensitizer in tumors, using proton therapy and the results have been promising. However, some quantitative studies should be conducted in order to examine the factors affecting this method. Methods: Monte Carlo simulation was performed by MCNPX code to assess pristine Bragg peak, spread-out bragg peak (SOBP), and secondary particle production enhancement in GNPs radio-sensitized tumor using proton therapy. Results: The results show several percent dose enhancement within and its reduction after the tumor site. A little increase in neutron production and no deviation for photon production is indicated. Conclusions: Finally, it can be concluded that sensitization of a realistic tumor can be beneficial during the proton therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::200030200883169c1e377fb957d5fe60 https://doi.org/10.5812/ijcm.10719 Zobrazit plný text záznamu