The Rapid and Spontaneous Postpartum Clearance of Plasmodium falciparum Is Related to Expulsion of the Placenta

Autor:	Nsoh G Anabire, Maria del Pilar Quintana, Michael F Ofori, Lars Hviid
Rok vydání:	2023
Předmět:	Infectious Diseases Immunology and Allergy
Zdroj:	The Journal of Infectious Diseases.
ISSN:	1537-6613 0022-1899
DOI:	10.1093/infdis/jiad031
Popis:	Parasitemia among pregnant women with protective immunity to Plasmodium falciparum malaria is often dominated by VAR2CSA-positive infected erythrocytes (IEs). VAR2CSA mediates sequestration of IEs in the placenta. We hypothesized that the previously observed spontaneous postpartum clearance of parasitemia in such women is related to the expulsion of the placenta, which removes the sequestration focus of VAR2CSA-positive IEs. We assessed parasitemias and gene transcription before and shortly after delivery in 17 Ghanaian women. The precipitous decline in parasitemia postpartum was accompanied by selective reduction in transcription of the gene encoding VAR2CSA. Our findings provide a mechanistic explanation for the earlier observation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1fffc8a8a874ad27e19e13e5e83d019e https://doi.org/10.1093/infdis/jiad031 Zobrazit plný text záznamu