| Autor: |
Martina Kerscher, Claus Gruss, M. Freitag, Thomas Dirschka, Gregor von Kobyletzki, Matthias Volkenandt, Tilmann Reuther, Peter Altmeyer |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Journal of the American Academy of Dermatology. 38:21-26 |
| ISSN: |
0190-9622 |
| DOI: |
10.1016/s0190-9622(98)70533-x |
| Popis: |
Background: For treatment of localized scleroderma numerous treatments, including ones with potentially hazardous side effects, are currently used with only limited success. Objective: We attempted to determine the efficacy of low-dose UVA 1 irradiation in patients with severe localized scleroderma. Methods: Patients were irradiated with 20 J/cm 2 UVA 1 for 12 weeks (total number of treatments: 30; cumulative UVA 1 dose: 600 J/cm 2 ). Results: Low-dose UVA 1 irradiation induced significant clinical improvement (clearance of>80% of lesions) in 18 of 20 patients. Clearance was documented by clinical score as well as by 20 MHz ultrasound and histopathologic analysis. Conclusion: Low-dose UVA 1 phototherapy can be highly effective for sclerotic plaques, even in patients with advanced localized scleroderma and with lesions rapidly evolving despite conventional therapy. (J Am Acad Dermatol 1998;38:21-6.) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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