Focused Dual-energy CT Maintains Diagnostic and Compositional Accuracy for Urolithiasis Using Ultralow-dose Noncontrast CT

Autor: Arkadiusz Miernik, Mathias Langer, Fabian Adams, Daniel Schlager, Simon Hein, Stefan Bulla, G. Pache, Konrad Wilhelm, Sabina Sevcenco, Martin Schoenthaler, Franklin E. Kuehhas
Rok vydání: 2015
Předmět:
Zdroj: Urology. 86:1097-1103
ISSN: 0090-4295
DOI: 10.1016/j.urology.2015.06.052
Popis: Objective To evaluate the diagnostic accuracy of a new energy and radiation dose–reduced protocol for noncontrast computed tomography (NCCT) with dual-energy CT (DECT) analysis and its potential for the compositional analysis of uric acid (UA)- or non–uric acid (N-UA)-containing calculi. Methods A retrospective evaluation was carried out in 61 patients who underwent dose-reduced DECT (tube A: 140 kV/55 mAs; tube B: 80 kV/303 mAs) with a tube current 38.8% lower than that set by the manufacturer. A protocol combining low-dose CT and targeted DE scans was used. Urinary stones were detected and classified as UA- or N-UA-containing or mixed based on DE software results. The accuracy of the compositional analysis was controlled by correlation with conventional infrared-based analysis. Results The compositional stone differentiation was correct in 58 of 61 (95.1%) patients. The sensitivity of detecting pure UA-containing and pure N-UA-containing stones was 100%. The specificity of detecting UA- and pure N-UA-containing stones was 100% and 78.57%, respectively, as 3 of 7 mixed urinary stones (small fragments 25 kg/m2 was 1.2 and 2.5 mSv, respectively. Conclusion Lowering the DECT tube current by up to 38% of the manufacturer's recommendations allows a reduced radiation dose without impairing detection accuracy and stone compositional analysis. Compared with previous studies, this protocol might significantly decrease patient radiation exposure without affecting the quality of results.
Databáze: OpenAIRE