Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0

Autor:	Donna M. Simmons, Michael G. Rosenfeld, Larry W. Swanson, R. E. Park, Chijen R. Lin, Xi He, R. Gerrero
Rok vydání:	1991
Předmět:	POU domain L1 Cell adhesion molecule Schwann cell Cell Biology Biology bacterial infections and mycoses Molecular biology Gene product medicine.anatomical_structure nervous system medicine TFEB Gene family Molecular Biology Transcription factor
Zdroj:	Molecular and Cellular Biology. 11:1739-1744
ISSN:	1098-5549 0270-7306
DOI:	10.1128/mcb.11.3.1739
Popis:	Tst-1, a member of the POU domain gene family, is expressed in specific neurons and in myelinating glia in the mammalian nervous system. Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein P0, a Schwann cell surface adhesion molecule. In cotransfection assays, Tst-1 can specifically repress the P0 promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1ffd3bab0559794b3d9d90d7f450d776 https://doi.org/10.1128/mcb.11.3.1739 Zobrazit plný text záznamu