Virulence and Immunogenicity in Mice of Airborne Encephalomyocarditis Viruses and Their Infectious Nucleic Acids

Autor:	T. G. Akers, S. B. Bond, C. Papke, W. R. Leif
Rok vydání:	1966
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 97:379-385
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.97.3.379
Popis:	Summary Mice were exposed to aerosols of different strains of the encephalomyocarditis virus group. Responses in mice were different according to strains, virulence being correlated with plaque size. Small plaque-forming strains, ME and Mengo-37A (a heat-resistant mutant of Mengo), were essentially avirulent. The avirulent strains were immunogenic when in sufficient concentration. Aerosol studies with infectious RNA extracted from Mengovirus, ME, and Mengo-37A indicated that the responses in mice were similar to those observed with intact virus. Mengovirus RNA aerosols were lethal for mice, whereas Mengo-37A and ME RNA were avirulent and were not immunogenic in the limited aerosol concentration tested. Mice immunized with intact Mengo-37A virus were refractory to Mengo RNA aerosol challenge.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1fee3319ef5fdda5d373a16a5d1f5c2a https://doi.org/10.4049/jimmunol.97.3.379 Zobrazit plný text záznamu