Studies on Platelets
| Autor: | Mario Stefanini, Edward Adelson |
|---|---|
| Rok vydání: | 1952 |
| Předmět: | |
| Zdroj: | Blood. 7:700-709 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v7.7.700.700 |
| Popis: | 1. The serum of a patient with thrombotic thrombocytopenic purpura was found to contain an agglutinin active against sheep red cells and heterologous platelets (dog, rabbit and rat), but not against human platelets. The activity of the agglutinin was not affected by absorption with gels, treatment with ion-exchange resins, filtration through Seitz filters or heating of the serum at 56 C. The antibody was found to be present in the salt soluble fraction of the serum proteins. The agglutinin could not be eluted from the agglutinated platelets, was absorbed completely by guinea pig kidney and incompletely by beef erythrocyte antigen (Forssman’s variety). 2. Ability to agglutinate heterologous platelets was found to be a property of sera exhibiting a high titer of heterophil antibodies of the Forssman or non-Forssman variety. 3. It is not likely that the presence of such heterophil agglutinin was of importance in the pathogenesis of the hemolytic anemia and thrombocytopenia of the patient; rather, it could be an effect of the active lytic process of red cells and platelets. Whether the finding had diagnostic significance in the ill-defined syndrome of thrombotic thrombocytopenic purpura remains to be established with the observation of further cases. |
| Databáze: | OpenAIRE |
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