| Autor: |
Karam El-Bayoumy, Robert S. DiPaola, Susan Goodin, Matthew G. Kaag, Aaron Baker, Amy Ciccarella, Terryl J. Hartman, Arthur Berg, Eugene J. Lengerich, Jiangang Liao, Wanda Neidig, Raghu Sinha, Ana M. Calcagnotto, Arun Das, John P. Richie |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1940-6207.c.6544832 |
| Popis: |
Epidemiologic and laboratory studies indicate that dietary selenium protects against prostate cancer. Results from clinical trials suggest that selenium-enriched yeast (SY) but not selenomethionine (SeMet) may be effective at reducing prostate cancer risk. Our objectives were to directly compare for the first time the effects of SeMet and SY on prostate cancer relevant biomarkers in men. We performed a randomized double blind, placebo-controlled trial of SY (200 or 285 μg/day) and SeMet (200 μg/day) administered for 9 months in 69 healthy men. Primary endpoints included blood levels of selenium-containing compounds and oxidative stress biomarkers [urine 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin-F2α (8-iso-PGF2α) and blood glutathione (GSH)]. Secondary endpoints included plasma glucose and PSA levels. Compliance was high in all groups (>95%). Plasma selenium levels were increased 93%, 54%, and 86% after 9 months in SeMet and low- and high-dose SY groups, respectively, and returned to baseline levels after a 3-month washout (P < 0.05). Levels of 8-OHdG and 8-iso-PGF2α were decreased 34% and 28%, respectively, after 9 months in the high-dose SY group (P < 0.05). These decreases were greatest in individuals with low baseline plasma levels of selenium (Cancer Prev Res; 7(8); 796–804. ©2014 AACR. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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